Antibodies

Antibodies are proteins that protect you when an unwanted substance enters your body. Produced by your immune system, antibodies bind to these unwanted substances in order to eliminate them from your system. Another word for antibody is immunoglobulin.

Cytokines

Chemokines

Anti-Chemokine-Like Receptor 1 Antibody

Description

Recognizes Chemokine-Like Receptor 1 [CMKLR1].

Specifications

Form –

Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.

Storage –

Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Anti-CXC Chemokine Receptor 3 Antibody, CT domain

Description

CXCR3, a chemokine receptor, is highly similar to the interleukin 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS.

Specifications

Form –

Peptide-affinity purified immunoglobulin. Liquid in PBS with less than 0.1% sodium azide

Storage –

Maintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles.

Anti-C-C Chemokine Receptor 5 Antibody, NT

Description

HIV and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G-protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors (1,2). Among them, CCR5 is a principle coreceptor for macrophage- and dual-tropic HIV-1 strains fusion of entry of human white blood cells (3,4). The amino-terminal domain and the extracellular loops of CCR5 serve as HIV binding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

Specifications

Form –

Format: Purified Purified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.

Storage –

Store at 2-8°C for up to 12 months.

Anti-Macrophage-Derived Chemokine antibody produced in chicken

Description

This antibody will neutralize the biological activity of recombinant human MDC. The antibody shows 20% cross-reactivity with recombinant human MPIF-1, 10% cross-reactivity with recombinant human MIP-1δ and 1% cross-reactivity with recombinant mouse MDC, human HCC-1, human I-309, mouse MIP-1α, viral MIP-I, mouse MIP-1β and mouse MIP-1γ.

Specifications

Conjugate –

Unconjugate

Form –

Lyophilized from a 0.2 μm-filtered solution in phosphate buffered saline with 5% Trehalose.

Storage –

−20°C

Anti-C-X-C chemokine receptor type 5 (CXCR5) Antibody

Description

C-X-C chemokine receptor type 5 (CXCR5; Burkitt lymphoma receptor 1; Monocyte-derived receptor 15) is a G-protein coupled cytokine receptor that binds selectively to the CXCL13 (B lymphocyte chemoattractant) ligand, and mediates the development and function of the immune system. It is expressed in mature B cells, and facilitates the migration of B cells into follicles of the splenic white pulp, and enables deposition of antigen on follicular dendritic cells. It is also involved in the development of lymph nodes and Peyer’s patches. Previous studies have reported that the expression of CXCR5 increases in rheumatoid arthritis.

Specifications

Form –

Affinity purified Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage –

Stable for 1 year at 2-8°C from date of receipt.

Anti-C-X-C Chemokine Receptor 4 Antibody, NT

Description

Recognizes CXCR4, N-terminus.

Specifications

Form –

Format: Purified Protein A purified Purified IgG in PBS containing 0.02% sodium azide.

Storage –

Maintain 1 year at 4°C, from date of shipment. Do not freeze. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

Description

Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

Specifications

Form –

Format: Purified Purified IgG in PBS containing 0.02% sodium azide.

Storage –

Can be refrigerated at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.

Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, NT

Description

CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively (1-4). The seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by facktokine (6). CX3CR1 mediates leukocyte migration and adhesion.

Specifications

Form –

Format: Purified Purified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.

Storage –

Store at 2-8°C for up to 12 months.

Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop

Description

Specifications

Form –

Format: Purified

Interferons

Anti-Interferon α-2 Antibody

Description

We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Green Chemistry.

Specifications

Conjugate –

Unconjugate

Isotype –

IgG

Form –

Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin.

Storage –

2-8°C

Anti-Interferon-α/β Receptor 1 antibody produced in goat

Description

Interferon-α/β Receptor 1 is a dimeric, disulfide-linked protein that binds human interferons α and β. This receptor also interacts with Tyr kinase JAK1, and thereby regulates cellular signaling across the membranes . Anti-Interferon-α/β Receptor 1 is specific for recombinant human IFN-α/β R1 and does not react with recombinant human IFN-γ RI and IFN-γ RII.

Specifications

conjugate –

unconjugated

Form –

0.1-1 μg/mL Recombinant Human IFN-α/β R1, HeLa humancervical epithelial carcinoma cell line, K562 human chronic myelogenousleukemia cell line.

Storage –

−20°C

Anti-Interferon-β Antibody

Description

Interferon beta is a globular protein consisting of 5 alpha helices with a predicted molecular weight of 20 kDa. Due to glycosylation, however, the observed molecular weight is closer to 25 kDa by SDS-PAGE.

Specifications

Form –

Rabbit Serum diluited with PBS. Liquid containing no preservatives. Unpurified

Storage –

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing.

Anti-Interferon β antibody produced in goat

Description

Type I interferons are proteins produced in response to inducers like viral infection and can be divided into α and β subtypes.

Specifications

Conjugate –

unconjugated

Form –

lyophilized powder

Storage –

−20°C.

Anti-Interferon γ Antibody

Description

recombinant, expressed in HEK 293 cells

Specifications

Conjugate –

unconjugated

Isotype –

IgG

Form –

lyophilized

Storage –

2-8°C

Anti-Interferon-γ antibody produced in goat

Description

Interferons (IFNs) are cytokines that are secreted in response to viral or bacterial infections and tumorigenesis. There are two types of IFNs, type I (IFN-α and IFN-β) and type II (IFN-γ).

Specifications

Form –

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Storage –

−20°C

Anti-Interferon Lambda 4, clone 4G1 Antibody

Description

Interferon Lambda 4, also known as IFN-lambda-4, and encoded by the gene IFNL4, is an important cytokine that forms part of our innate immunity against viruses.

Specifications

Concentration –

1 mg/mL

Isotype –

IgG1k

Form –

Format: Purified

CD4 Antibody Panel

Description

IFN α 2 is a protein that belongs to family of pleiotropic cytokines produced by macrophages in response to pathogens. It plays a crucial role in antiviral activities. Anti-interferon α2 antibody (1:200) can be used for cell or tissue staining. Chicken anti- interferon α2 antibody reacts specifically with human recombinant interferon protein α 2.

Specifications

Conjugate –

Unconjugated

Form –

Solution in phosphate buffered saline containing 0.02% sodium azide.

Storage –

−20°C

Monoclonal Anti-Interferon-γ antibody produced in mouse

Description

Monoclonal Anti-Interferon-γ antibody produced in mouse

Specifications

Conjugate –

unconjugated

Isotype –

IgG2a

Form –

lyophilized powder

Storage –

−20°C.

Monoclonal Anti-Interferon-γ antibody produced in rat

Description

Interferon-γ (IFN-γ) belongs to Type II class of interferons and is produced by T helper cells (specifically, Th1 cells), natural killer (NK) and natural killer T (NKT) cells and cytotoxic T cells (TC cells) . It has various biological functions including antiviral activity like inhibition of cell or tumor growth, act as a potent modulator of immune responses and modifies cellular processes as well as stimulates the differentiation of B cells into immunoglobulin-producing cells. Monoclonal Anti-Interferon-γ antibody can be used in immunoblotting. Rat anti-Interferon-γ antibody has shown no cross-reactivity for recombinant human IFN-γ or recombinant rat IFN-γ.

Specifications

Conjugate –

unconjugated

Isotype –

IgG2a

Form –

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline and 5% trehalose.

Storage –

−20°C.

Interleukins

Anti-Interleukin-6 Antibody

Description

Anti-Interleukin-6 Antibody

Specifications

Isotype –

IgG

Form –

Rabbit serum. Liquid containing 0.1% sodium azide.

Storage –

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Anti-Interleukin-8 Antibody

Anti-CD4 Antibody (human), APC

Description

Interleukin-8 (IL-8) is a chemokine produced by macrophages, epithelial cells and endothelial cells. IL-8′s primary function is to recruit neutrophils to phagocytose the antigen which trigger the antigen pattern toll-like receptors.

Specifications

Conjugate –

Unconjugate

Isotype –

IgG

Form –

Format: Purified Liquid in PBS, no preservatives. Protein A purified

Storage –

Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.

Anti-Interleukin-1β Antibody

Description

Anti-Interleukin-1β Antibody

Specifications

Form –

Affinity purified Immunoglobulin. Lyophilized from 0.5X PBS pH 7.4, no preservatives. Reconstitute in sterile distilled water.

Storage –

Maintain lyophilized material desiccated below 0°C. After reconstitution maintain at -20°C in convenient undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Anti-Interleukin-10 Antibody

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Storage –

−20°C

Anti-Interleukin-12 antibody produced in goat

Description

Interleukin-12 (IL-12) is an important cytokine that links innate and adaptive immunity. It plays a role in the regulation of Th1-associated cellular immunity to foreign pathogens, and humoral immunity to antigens that are both T cell-independent and T cell-dependent.

Specifications

Conjugate –

unconjugated

Isotype –

IgG

Form –

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Storage –

−20°C

Anti-Interleukin-10 antibody produced in goat

Description

Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens.

Specifications

Conjugate –

unconjugated

Isotype –

IgG

Form –

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Storage –

−20°C

Anti-Interleukin-1α antibody produced in goat

Description

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS.

Specifications

Conjugate –

unconjugated

Isotype –

IgG

Form –

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline pH 7.4, with 5% trehalose.

Storage –

−20°C

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Human TNF alpha Matched Antibody Pair Kit

Description

Human TNF alpha Matched Antibody Pair Kit

Specifications

Storage –

Store at -20°C. Please refer to protocols.

Monoclonal Anti-TNF antibody produced in mouse

Description

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.

Specifications

Conjugate –

unconjugated

Isotype –

IgG1κ

Form –

Solution in phosphate buffered saline, pH 7.4

Storage –

−20°C.

Anti-TNF-alpha induced protein 6 (TSG-6) Antibody

Description

Tumor Necrosis Factor-alpha (TNF-alpha), also known as TSG-6, is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. The mature form of human TNF-alpha has 157 amino acid residues. TNF-alpha induced protein 6 may be involved in cell-cell and cell-matrix interactions during normal inflammatory responses and during tumorigenesis.

Specifications

Conjugate –

Unconjugate

Isotype –

IgG2bκ

Form –

Format: Purified Protein G Purified Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage –

Stable for 1 year at 2-8°C from date of receipt.

Anti-TNFα Receptor Antibody

Description

Tumor necrosis factor receptor superfamily member 1A (UniProt P19438; also known as CD120a, p55, p60, TNF-R1, TNF-RI, TNFR-I, Tumor necrosis factor-alpha receptor, Tumor necrosis factor receptor type 1) is encoded by the TNFRSF1A (also known as FPF, MS5, TNFAR, TNFAR55, TNFAR60, TNFR1) gene (Gene ID 7132) in human.

Specifications

Isotype –

IgG1κ

Form –

Format: Purified

Anti-TNF-α Rabbit pAb

Description

Rabbit polyclonal antibody purified by ammonium sulfate precipitation. Recognizes recombinant and monocyte-derived TNF-α.

Specifications

Conjugate –

Unconjugate

Isotype –

IgG

Form –

liquid

Storage –

−20°C

Monoclonal Anti-TNFalpha-APC antibody produced in mouse

Description

The mouse monoclonal antibody MAb11 recognizes human 17-26 kDa cytokine TNF-alpha (tumor necrosis factor alpha).

Specifications

Form –

Solution in phosphate buffered saline with 15 mM sodium azide.

Storage –

2-8°C

Stable for 1 year at 2-8°C from date of receipt.

Anti-CSF2 antibody produced in rabbit

Description

Anti-CSF2 antibody produced in rabbit

Specifications

Conjugate –

unconjugated

Form –

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Storage –

−20°C

Anti-CSF1 antibody produced in rabbit

Description

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants.

Specifications

Concentration –

3.66 mg/ml

Isotype –

IgG2a

Form –

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage –

Store at 4℃. Avoid freeze / thaw cycles.

Anti-M-CSF Receptor antibody produced in rabbit

Description

Anti-M-CSF Receptor Antibody detects endogenous levels of total M-CSF Receptor protein.

Specifications

Concentration –

~1 mg/mL

conjugate –

unconjugated

form –

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage –

−20°C